Institution name and department

Université de Montpellier (France)

Institut Charles Gerhardt de Montpellier (ICGM)

Position held


Associate Professor



8, Rue de l’Ecole Normale

34296 Montpellier (France)



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Key words


·       Medicinal mechanochemistry and APIs

·       Catalysis


·       Green Chemistry Education

·       Heterocycles


·       Green solvents

·       Enabling technologies


Areas of Research/Expertise 

The main research activities concern the development of eco-friendly methodologies for the preparation of biomolecules, small heterocyclic compounds and hybrid materials by mechanochemistry (dry or wet grinding), with a main focus on hydantoin scaffold and Active Pharmaceutical Ingredients (medicinal mechanochemistry). Sustainable approaches to homogeneous or heterogeneous metal-catalysed processes by combining enabling technologies (ultrasounds, microwaves, and flow systems) with non-conventional media [e.g., glycerol, water, poly(ethylene)glycols, and PEG-based ionic liquids] or in micellar conditions (in water and glycerol) are also investigated.

Promoter of sustainability in Higher Education by integrating green chemistry at undergraduate level in organic chemistry courses, teaching laboratories and across the sub-disciplines of chemistry, with a special focus on the fundamentals and the practice of mechanochemistry (

5 Most representative publications related to mechanochemistry

1.           Crawford, D.E.*; Porcheddu, A.; McCalmont, A.S.; Delogu, F.; James, S. L.; Colacino, E.* « Twin-Screw Extrusion for Hydrazone Synthesis, Generating Active Pharmaceutical Ingredients (APIs).” ACS Sustainaible Chem. Eng. 2020, 8, 12230–12238. DOI: 10.1021/acssuschemeng.0c03816. ACS Editors’ Choice, August 2020. Highlighted in C&EN (September 30, 2020). Special Virtual Issue ‘Advances in Mechanochemistry’ at the Occasion of INCOME2020 (Guest Editors: Timothy Hanusa, Francesco Delogu & Evelina Colacino)

2.           Porcheddu, A.*; Delogu, F.; De Luca, L.; Colacino, E.* “From Lossen Transposition to Solventless Medicinal Mechanochemistry” ACS Sustainable Chem. Eng., 2019, 7, 12044-12051. DOI: 10.1021/acssuschemeng.9b00709. CAS Registry Innovator program

3.           Colacino, E.*;  Dayaker, G.; Morère,  A.; Friščić,  T.* “Introducing  Students  to  Mechanochemistry  via an Environmentally-friendly Organic Synthesis using a Solvent-free Mechanochemical Preparation of Anti-diabetic Drug, Tolbutamide” J. Chem. Educ., 2019, 96, 766-771 DOI: 10.1021/acs.jchemed.8b00459 - Invited cover art.

4.           Colacino, E.*; Porcheddu, A.;* Halasz, I.; Charnay, C.; Delogu, F.; Guerra, R.; Fullenwarth, J. “Mechanochemistry for “no solvent, no base” preparation of Hydantoin-based Active Pharmaceutical Ingredients: Nitrofurantoin and Dantrolene” Green Chem. 2018, 20, 2973–2977. DOI: 10.1039/C8GC01345D. (Themed collection: 2018 Green Chemistry Hot Articles)

5.           Martina, K.; Rotolo, L.; Porcheddu, A.; Delogu, F.; Bysouth, S.R.; Cravotto, G.;* Colacino, E.* “ High Throughput Mechanochemistry: Application to Parallel Synthesis of Benzoxazines” Chem. Comm. 2018, 54, 551-554. DOI: 10.1039/C7CC07758K

5 Most representative publications non-related to Mechanochemistry

1.     Manzoli, M.; Calcio Gaudino, E.; Cravotto, G.;* Tabasso, S.; Baig, R. B. Nasir; Colacino, E.*; Varma, R.S.* “Microwave-assisted Reductive Amination with Aqueous Ammonia: Sustainable Pathway using Recyclable Magnetic Nickel-based Nano-catalyst” ACS Sustainable Chem. Eng., 2019, 7, 5963-5974. DOI: 10.1021/acssuschemeng.8b06054

2.     Mnasri, N.; Naylosaso, J.; Derrien, G.; Lamaty, F.; Martinez, J.; Zajac, J.; Charnay, C.*; Colacino, E.* ”Copper- containing rod-shaped nanosized silica particles for microwave assisted synthesis of triazoles in acqueous solutions” ACS Sustainable Chem. Eng. 2015, 3, 2516-2525. DOI: 10.1021/acssuschemeng.5b00661

3.     Hamel, A.; Sacco, M.; Mnasri, N.; Lamaty, F.; Martinez, J.; De Angelis, F.; Colacino, E*; Charnay, C.* “Micelles into glycerol solvent: Overcoming side reactions of glycerol” ACS Sustainable  Chem. Eng., 2014, 2, 1353- 1358. DOI: 10.1021/sc500207r (IF = 6.140)

4.     Giachi, G.; Frediani, M.; Oberhauser, W.; Lamaty, F.; Martinez, J.; Colacino, E.* “Ultrasounds in melted poly(ethylene glycol) enhance the copper-catalyzed cyanation of aryl halides with K4(Fe(CN)6)” ChemSusChem 2014, 7, 919-924 DOI:10.1002/cssc.201300997 (IF = 7.411)

5.     Azua, A.; Mata, J.A.;* Heymes, P.; Peris, E.; Lamaty, F.; Martinez, J.; Colacino, E.* “Palladium N-heterocyclic carbene Catalysts for Ultrasound-promoted Suzuki - Miyaura Reaction in Glycerol” Adv. Synth. Catal. 2013, 355, 1107-1116. DOI: 10.1002/adsc.201201047

Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID


Google Scholar



Evelina Colacino

Scopus profiles


Twitter/ Linkedin/ Instagram accounts




Instagram accounts

Evelina Colacino

Primary focus in mechanochemical research (enter as bullet points)

Tagged under

Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112