Eusebio Juaristi

With a doctoral thesis in stereochemistry and postdoctoral experience in carbanion and synthetic organic chemistry, Eusebio Juaristi returned to Mexico in 1979 to initiate formal research projects in physical organic chemistry. As an independent researcher in Mexico, Juaristi became leader in topics such as the anomeric effect and related stereoelectronic interactions, enantioselective synthesis of a- and b-amino acids, asymmetric organocatalysis, and green chemistry. His publications have received over 10,000 citations by other authors.

Eusebio Juaristi has directed 41 Ph. D., 24 M. Sc., and 60 B. Sc. research theses. Most of his former students have chosen academic careers, and are presently faculty members in several graduate chemistry programs in Mexico.

Juaristi has been quite active at the Mexican Chemical Society (organizing numerous courses, symposia, and scientific meetings), the Mexican Academy of Sciences (Director of the Latinamerican Chemistry Net www.relaq.mx, Chair of the Distinguished Professorship Program, etc.), and the Mexican Presidential Research Council.

Eusebio Juaristi has received many honors including the Award for Young Scientists 1988 bestowed by the Mexican Academy of Sciences, the Interamerican Prize in Science and Technology granted by the Organization of American States in 1990, recipient of the National Chemistry Award in 1994, the Presidential Medal in 1998, and the Heberto Castillo Award in 2019. Furthermore, he became a member of “El Colegio Nacional” (highest academic honor in Mexico) in 2006. In 2013 he received the Georg Forster Award (Alexander von Humboldt Foundation), and in 2019-2020 a Tinker Visiting Professorship (Stanford University).

1. Hernández, J. G.; Juaristi, E. “A Green Synthesis of a,b- and b,b-Dipeptides under Solvent-Free Conditions”, J. Org. Chem. 2010, 75, 7107-7111. https://doi.org/10.1021/jo101159a
2. Hernández, J. G.; Juaristi, E. “Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline-Containing Dipeptides: Improved Stereoinduction under Solvent-Free Conditions”, J. Org. Chem. 2011, 76, 1464-1467. https://doi.org/10.1021/jo1022469
3. Polindara-García, L. A.; Juaristi, E. "Synthesis of Ugi-4CR and Passerini-3CR Adducts Under Mechanochemical Activation", Eur. J. Org. Chem. 2016, 2016, 1095-1102. https://doi.org/10.1002/ejoc.201501371
4. Landeros, J. M.; Juaristi, E. "Mechanochemical Synthesis of Dipeptides Using Mg-Al Hydrotalcite as Catalyst Under Solvent-Free Reaction Conditions", Eur. J. Org. Chem. 2017, 2017, 687-694. https://doi.org/10.1002/ejoc.201601276
5. Pérez-Venegas, M.; Juaristi, E. "Mechanoenzymatic Resolution of Racemic Chiral Amines, A Green Technique for the Synthesis of Pharmaceutical Building Blocks", Tetrahedron 2018, 74, 6453-6458. https://doi.org/10.1016/j.tet.2018.09.029
6. Pérez-Venegas, M.; Téllez-Cruz, M. M.; Solorza-Feria, O.; López-Munguía, A.; Castillo, E.; Juaristi, E. "Thermal and Mechanical Stability of Immobilized Candida Antartica Lipase B: an Approximation to Mechanochemical Energetics in Enzymatic Catalysis, ChemCatChem, in press. https://doi.org/10.1002/cctc.201901714

1. Juaristi, E.; Quintana, D.; Lamatsch, B.; Seebach, D. “Asymmetric Synthesis of b-Amino Acids. Highly Diastereoselective Addition of Chiral b-Alanine Enolate Derivatives to Electrophiles”, J. Org. Chem. 1991, 56, 2553-2557. https://doi.org/10.1021/jo00007a053 (b) Juaristi, E.; D. Quintana, J. Escalante, “Enantioselective Synthesis of b-Amino Acids”, Aldrichimica Acta 1994, 27, 3-11. https://www.sigmaaldrich.com/ifb/acta/v27/HTML/4/index.html (c) Juaristi, E. Ed., “Enantioselective Synthesis of b-Amino Acids”, Wiley-VCH: New York, 1997. DOI:10.1002/0471698482

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   P. Zubrzak, H. Williams, G.M. Coast, R.E. Isaac, G. Reyes-Rangel, E. Juaristi, J. Zabrocki, R.J. Nachman, “b-Amino Acid Analogs of an Insect Neuropeptide Feature Potent Bioactivity and Resistance to Peptidase Hydrolysis”, Biopolymers, Peptide Science, 2007, 88, 76-82. https://doi.org/10.1002/bip.20638

3. Juaristi, E.; Cuevas, G. “Recent Studies of the Anomeric Effect”, Tetrahedron 1992, 48, 5019-5087. https://doi.org/10.1016/S0040-4020(01)90118-8 

4. Juaristi, E.; Cuevas, G. “Manifestations of Stereoelectronic Interactions in 1JC-H One Bond Coupling Constants”, Acc. Chem. Res. 2007, 40, 961-970. https://doi.org/10.1021/ar6000186

5. Juaristi, E.; Notario, R. "Theoretical Evidence for the Relevance of n(F)→ σ*(C–X) (X = H,C,O,S) Stereoelectronic Interactions", J. Org. Chem. 2016, 81, 1192-1197. https://doi.org/10.1021/acs.joc.5b02718 

6. Juaristi, E.; dos Passos Gomes, G.; Terent’ev, A. O.; Notario, R.; Alabugin, I. V.; “Stereoelectronic Interactions as a Probe for the Existence of the Intramolecular α Effect”, J. Am. Chem. Soc. 2017, 139, 10799-10813. https://doi.org/10.1021/jacs.7b05367 

7. Hernández, J. G.; Juaristi, E. “Recent Efforts Directed to the Development of More Sustainable Asymmetric Organocatalysis”, Chem. Commun. 2012, 48, 5396-5409. https://doi.org/10.1039/C2CC30951C

8.  Obregón-Zúñiga, A.; Milán, M.; Juaristi, E. Improving the Catalytic Performance of (S)-Proline as Organocatalyst in Asymmetric Aldol Reactions in the Presence of Solvate Ionic Liquids: Involvement of a Supramolecular Aggregate. Org. Lett. 2017, 19, 1108-1111. https://doi.org/10.1021/acs.orglett.7b00129

Orcid ID: 0000-0003-0936-7020
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• Solvent-free organic synthesis
• Multicomponent reactions under mechanochemical conditions
• Mechanoenzymatic reactions