Tomislav Friščić

My research group is generally developing new synthetic designs based on solvent- free chemistry, including mechanochemistry, ageing reactivity and thermochemistry. We are developing mechanochemistry in the context of applications (Green chemistry, pharmaceuticals, nanomaterials, metal-organic frameworks, cocrystals, metal and plastics recycling, mechano-enzymatic reactions, biomass chemicals), as well as fundamental understanding. In the context of understanding mechanochemical reactivity, we are pursuing the use and development of in situ monitoring techniques, as well as theoretical modelling approaches based on periodic density functional theory (DFT) modelling, and molecular dynamic (MD).

1. Julien, P. A.; Germann, L. S.; Titi, H. M.; Etter, M.; Dinnebier, R. E.; Sharma, L.; Baltrusaitis, J.; Friščić, T. “In situ monitoring of mechanochemical synthesis of calcium urea phosphate fertilizer cocrystal reveals highly effective water-based autocatalysis“ Chem. Sci. 2020, 11, 2350-2355. https://doi.org/10.1039/C9SC06224F
2. Friščić, T.; Mottillo, C.; Titi, H. M. “Mechanochemistry for synthesis“ Angew. Chem. Int. Ed. 2020, 59, 1018-1029. https://doi.org/10.1002/anie.201906755
3. Kaabel, S.; Stein, R. S.; Fomitšenko, M.; Järving, I.; Friščić, T.; Aav, R. “Size-control by anion templating in mechanochemical synthesis of hemicucurbiturils in the solid state“ Angew. Chem. Int. Ed. 2019, 58, 6230-6234. https://doi.org/10.1002/anie.201813431
4. Hammerer, F.; Loots, L.-A.; Do, J.-L.; Therien, J. P. D.; Nickels, C. W.; Friščić, T.; Auclair, K. ”Solvent-free enzyme activity: quick, high-yielding mechano-enzymatic hydrolysis of cellulose into glucose" Angew. Chem. Int. Ed. 2018, 57, 2621-2624. https://doi.org/10.1002/anie.201711643
5. Friščić, T.; Halasz, I.; Beldon, P. J.; Belenguer, A. M.; Adams, F.; Kimber, S. A. J.; Honkimäki, V.; Dinnebier, R. E. "Real-time and in situ monitoring of mechanochemical reactions" Nature Chemistry, 2013, 5, 66-73. https://doi.org/10.1038/nchem.1505

1. Titi, H. M.; Marrett, J. M.; Dayaker, G.; Arhangelskis, M.; Mottillo, C.; Morris, A. J.; Rachiero, G. P.; Friščić, T.; Rogers, R. D. “Hypergolic Zeolitic Imidazolate Frameworks (ZIFs) as Next-Generation Solid Fuels: Unlocking the Latent Energetic Behavior of ZIFs“ Science Adv. 2019, 5, eaav9044. DOI: 10.1126/sciadv.aav9044
2. Lisac, K.; Topić, F.; Arhangelskis, M.; Cepić, S.; Julien, P. A.; Nickels, C. W.; Morris, A. J.; Friščić, T.; Cinčić, D. ”Halogen bonds to phosphorus, arsenic and antimony" Nature Commun. 2019, 10:61 https://doi.org/10.1038/s41467-018-07957-6
3. Huskić, I.; Pekov, I.; Krivovichev, S.; Friščić, T. "Minerals with Metal-Organic Framework Structures" Science Adv. 2016, 2, e1600621 DOI: 10.1126/sciadv.1600621
4. Bushuyev, O. S.; Corkery, T. C.; Barrett, C. J.; Friščić, T. "Photo-mechanical azobenzene co-crystals and in situ X-ray diffraction study of their optically-induced crystal-to-crystal isomerization" Chem. Sci. 2014, 5, 3158-3164.  https://doi.org/10.1039/C4SC00987H
5. Cliffe, M. J. C.; Mottillo, C.; Stein, R. S.; Bučar, D.-K.; Friščić, T. "Accelerated aging: a low energy, solvent-free alternative to solvothermal and mechanochemical synthesis of metal-organic materials" Chem. Sci. 2012, 3, 2495-2500.  https://doi.org/10.1039/C2SC20344H

Orcid ID: 0000-0002-3921-7915
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