Tom Leyssens

My main area of research orients towards multi-component crystal structures and the applications thereof. I work in the field of pharmaceutically active compounds. We look into developing resolution processes, purification/separation processes, … Recently we try to tap into the mechochemical potential of multi-component systems.

1. Shemchuk, O.; Song, L.; Robeyns, K.; Braga, D.; Grepioni, F.; Leyssens, T. Chem. Comm. 2018,54 (77), 10890-10892. Solid-state Chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2. DOI 10.1039/C8CC06199H
2. Springuel, G.; Norberg, B. ; Robeyns, K. ; Wouters, J. ; Leyssens, T. Cryst. Growth Des. 2012, 12, 475-484. Advances in pharmaceutical co-crystal screening: Effective co-crystal screening through structural resemblance. DOI 10.1021/cg201291k
3. George, F. ; Tumanov, N. ; Norberg, B. ; Robeyns, K. ; Filinchuk, Y.; Wouters, J.; Leyssens, T. Cryst. Growth Des. 2014, 14, 2880-2892. Does chirality influence the tendency toward cocrystal formation. doi/10.1021/cg500181t
4. Springuel, G.; Robeyns, K. ; Norberg, B.; Wouters, J. ; Leyssens, T. Cryst. Growth Des. 2014, 14, 3996-4004. Cocrystal formation between chiral compounds: how cocrystals differ from salts doi/10.1021/cg500588t
5. Carletta, A. ; Buol, X. ; Leyssens, T. ; Champagne, B. ; Wouters, J. J. Phys. Chem. C. 2016, 120, 10001- 10008. Polymorphic and isomorphic cocrystals of N-alicylidene-3-aminopyridine with dicarboxylic acids: tuning of solid-state photo- and thermochromism. doi/10.1021/acs.jpcc.6b02734

1. Harmsen, B.; Leyssens, T. Cryst. Growth Des. 2018, 18, 3654-3660. Enabling enantiopurity: combining racemization and dual-drug co-crystal resolution. DOI /10.1021/acs.cgd.8b00438
2. Shemchuk, O.; Song, L.; Robeyns, K.; Braga, D.; Grepioni, F.; Leyssens, T. Chem. Comm. 2018,54 (77), 10890-10892. Solid-state Chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2. DOI 10.1039/C8CC06199H 
3. Leyssens, T.; ter Horst, J.H. in Multi-component Crystals: Synthesis, Concepts, Function De Gruyter, p. 205-236. Solution co-crystallization and its applications. ISBN 978-3-11-046495-5 
4. Leyssens, T.; Springuel, G.; Montis, R. ; Candoni, N. ; Veesler, S. Cryst. Growth Des. 2012, 12, 1520- 1530. Importance of solvent selection for stoichiometrically diverse cocrystal systems. doi/10.1021/cg201581z

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Google Scholar:  https://scholar.google.be/citations?user=0bIeRGcAAAAJ&hl=nl
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Scopus profiles: https://www.scopus.com/authid/detail.uri?authorId=9535303000

• Contacts with mechnochemical community
• Expanding research and in particular focusing on API