Constantinos Athanassopoulos

Medicinal and synthetic organic chemistry in the fields of anticancer and antimicrobial agents, with special attention in targeting resistant cancer cells and bacteria.

The chemical modification of naturally occurring bioactive organic compounds (polyamines, retinoids, psoralens, chloramphenicol, abietane diterpenes etc.) and synthetic drugs aiming to alter their biological profile (enhance or modify their activity and/or improve their selectivity).

We are interested in the implementation of Mecahnochemistry steps in our synthetic procedures and especially for building heterocyclic scaffolds.

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1. Kalantzi, S.; Athanassopoulos, C. M.; Ruonala, R.; Helariutta, Y.; Papaioannou, D., General Approach for the Liquid-Phase Fragment Synthesis of Orthogonally Protected Naturally Occurring Polyamines and Applications Thereof. J Org Chem 2019, 84 (23), 15118-15130.

2. Giannopoulou, P. C.; Missiri, D. A.; Kournoutou, G. G.; Sazakli, E.; Papadopoulos, G. E.; Papaioannou, D.; Dinos, G. P.; Athanassopoulos,* C. M.; Kalpaxis, D. L., New Chloramphenicol Derivatives from the Viewpoint of Anticancer and Antimicrobial Activity. Antibiotics (Basel) 2019, 8 (1)

3. Magoulas, G. E.; Tsigkou, T.; Skondra, L.; Lamprou, M.; Tsoukala, P.; Kokkinogouli, V.; Pantazaka, E.; Papaioannou, D.; Athanassopoulos,* C. M.; Papadimitriou, E., Synthesis of nοvel artemisinin dimers with polyamine linkers and evaluation of their potential as anticancer agents. Bioorganic and Medicinal Chemistry 2017, 25 (14), 3756-3767.

4. Sonia Stoica, G. E. M., Antonia I. Antoniou, Sherif Suleiman, Analisse Cassar, Lucienne Gatt, Dionissios Papaioannou, Constantinos M. Athanassopoulos*, Pierre Schembri-Wismayer*, Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents. Bioorganic & Medicinal Chemistry Letters 2016.

5. Antoniou, A. I.; Pepe, D. A.; Aiello, D.; Siciliano, C.; Athanassopoulos,* C. M., Chemoselective Protection of Glutathione in the Preparation of Bioconjugates: The Case of Trypanothione Disulfide. The Journal of Organic Chemistry 2016, 81 (10), 4353-4358.

Orcid ID: https://orcid.org/0000-0002-7549-1911
Google Scholar: https://scholar.google.gr/citations?hl=en&user=4YtF6x0AAAAJ
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