Teresa Duarte

My main interests are in the use of Crystal Engineering and Supramolecular Synthesis to design and fabricate new solid forms of known active pharmaceutical molecules (API), to provide them with enhanced properties. Aiming to improve API bioavailability we have been searching for new solid forms, such as salts, molecular salts, solvates and co-crystals to modify and stabilize their physicochemical properties and controlling polymorphism. New API Ionic Liquid forms were also attained, avoiding polymorphism. Still searching for new and stable forms of pharmaceutically active molecules, we developed a novel approach, the synthesis of bio-inspired Metal-Organic Frameworks, BioMOFs, using safe metal ions and active biomolecules as spacers or guests are underway. These systems are being designed for application in drug storage and delivery. In the diversity of systems we have been studying and developing, we recurred to Mechanochemistry as main synthetic approach. Mechanochemistry a solvent free and environmentally friendly synthetic technique has proved to be efficient, has granted good yields and selectivity has also been an important issue.Different techniques are being used in the characterization of the products obtained, with special relevance for X-ray powder and single crystal diffraction. Structure solution from single crystal data is a long term established activity within the group. Diffraction data on powder samples are being collected at the European Synchrotron Radiation Facility in Grenoble and we have recently started to solve structures from powder data.

1. Inês C. B. Martins, Mariana Sardo, Edith Alig, Lothar Fink, Martin U. Schmidt, Luís Mafra, M. Teresa Duarte “Enhancing Adamantylamine Solubility through Salt Formation: Novel Products Studied by X-ray Diffraction and Solid-State NMR” Crystal Growth & Design 2019, 19, 3, 1860-1873 (DOI: 10.1021/acs.cgd.8b01830)
2. Oleksii Shemchuk, Boryana K. Tsenkova, Dario Braga, M. Teresa Duarte, Vânia André,Fabrizia Grepioni “Ionic Co-Crystal Formation as a Path Towards Chiral Resolution in the Solid State” Chem. Eur. J. 2018, 24, 1 – 11, https://doi.org/10.1002/chem.201802446
3. Inês C. B. Martins, M. Conceição Oliveira, Hermínio P. Diogo, Luís C. Branco, M. Teresa Duarte “MechanoAPI-ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis” ChemSusChem 2017, 10, 1360 – 1363 (DOI: 10.1002/cssc.201700153)
4. Quaresma, S.; André, V.; Fernandes, A.; Duarte, M. T. Mechanochemistry - a green methodology leading to metallodrugs, metallopharmaceuticals and bio-inspired metal-organic frameworks, Inorganica Chimica Acta 2017, 455(2), 309-318 (DOI: 10.1016/j.ica.2016.09.033)
5. Clara S.B.Gomes, Pedro T.Gomes, M. TeresaDuarte “alpha-Diimine transition-metal complexes: Mechanochemistry - A new synthetic approach” Journal of Organometallic Chemistry, 2014, 760, 101–107. DOI: 10.1016/j.jorganchem.2013.11.040 André, V.; Hardeman, A.; Halasz, I.; Stein, R. S.; Jackson, G. J.; Reid, D. G.; Duer, M. J.; Curfs, C.; Duarte, M. T.; Friščić, T. Mechanosynthesis of the metallodrug bismuth subsalicylate from Bi2O3 and structure of bismuth salicylate without auxiliary organic ligands, Angewandte Chemie International Edition, 2011, 50(34), 7858-7861 (DOI: 10.1002/anie.201103171)

1. Quaresma, S.; André, V.; Antunes, A. M. M.; Vilela, S. M. F.; Amariei, G.; Arenas-Vivo, A.; Rosal, R.; Horcajada, P.; Duarte, M.T. Novel antibacterial azelaic acid BioMOFs, Crystal Growth & Design 2019, ASAP (DOI: 10.1021/acs.cgd.9b01302)
2. Tiago F. C. Cruz, Karina Shimizu, José M. S. S. Esperança, Vânia André, M. Teresa Duarte, Luís P. N. Rebelo, Pedro T. Gomes, José N. Canongia Lopes, “Ionic Liquids in Wonderland: From Electrostatics to Coordination Chemistry”, J. Phys. Chem. C 2019, 123, 9, 5804-5811 (DOI: 10.1021/acs.jpcc.9b00987 )
3. Inês C.B. Martins, Mariana Sardo, Tomaž Čendak, José R.B. Gomes, João Rocha M. Teresa Duarte Luís Mafra, “Hydrogen bonding networks in gabapentin protic pharmaceutical salts: NMR and in silico studies”, Magn Reson Chem. 2019; 57:243–255 (DOI: 10.1002/mrc.4809 )
4. Inês C. B. Martins, José R. B. Gomes, M. Teresa Duarte, Luís Mafra “Understanding Polymorphic Control of Pharmaceuticals Using Imidazolium-Based Ionic Liquid Mixtures as Crystallization Directing Agents”, Crystal Growth & Design, 2017, 17, 2, 428-432 (DOI: 10.1021/acs.cgd.6b01798)
5. Clara S. B. Gomes, Alejandro F. G. Ribeiro, Anabela C. Fernandes, Artur Bento, M. Rosário Ribeiro, Gabriele Kociok- Köhn, Sofia I. Pascu, M. Teresa Duarte, Pedro T. Gomes “Reactivity of cationic α-diimine cyclopentadienyl nickel complexes towards AlEt2Cl: synthesis, characterisation and ethylene polymerisation” Catalysis Science & Technology, 2017, 7, 3128, (DOI: 10.1039/C7CY00875A)

Orcid ID: https://orcid.org/0000-0003-0994-1352
Google Scholar: https://scholar.google.pt/citations?user=V7KX794AA AAJ&hl=pt-PT
Researchgate: -
Scopus profiles: https://www.scopus.com/authid/detail.uri?authorId=6505770075

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