Tamara Hamilton

Consisting of only undergraduates, the Hamilton research group is interested in exploring greener methods of chemical synthesis, especially for porphyrins. Having shown the possibility of obtaining symmetrical, tetra-substituted porphyrins using simple starting materials through mechanochemistry, we are now investigating mechanochemical synthesis of di-substituted porphyrins, and those having very bulky substituents. We are also developing ways of teaching green chemistry using mechanochemical methods in undergraduate teaching labs. Another area of interest is metal-organic assemblies involving porphyrins as ligands.

1. “Extending mechanochemical porphyrin synthesis to bulkier aromatics: tetramesitylporphyrin’ Su, Q.; Hamilton, T. D. Beilstein J. Org. Chem. 2019, 15, 1149–1153. doi:10.3762/bjoc.15.111
2. “Two-step Mechanochemical Synthesis of Porphyrins” Shy, H.; Mackin, P.; Orvieto, A. S.; Gharbharan, D.; Peterson, G. R.; Bampos, N.; Hamilton, T. D. Faraday Discuss. 2014, 170, 59-69. 10.1039/C3FD00140G

1. “A metal-organic framework with three cavities based on three-coloured square tiling derived from a cyclobutane constructed in the solid state” Hamilton, T. D.; Bucar, D.-K.; MacGillivray, L. R. New J. Chem. 2010, 34, 2400-2402. 10.1039/C0NJ00367K
2. “Engineering New Metal-Organic Frameworks Built from Flexible Tetrapyridines Coordinated to Cu(II) and Cu(I)" Ryan, P.; Lescop, C.; Laliberte, D.; Hamilton, T.; Maris, T.; Wuest, J. Inorg. Chem. 2009, 48, 2793-2807. https://pubs.acs.org/doi/10.1021/ic8019809
3. “Onion-Shell Metal-Organic Polyhedra (MOPs): A General Approach to Decorate the Exteriors of MOPs Using Principles of Supramolecular Chemistry” T. D. Hamilton, G. S. Papaefstathiou, T. Friščić, D.-K. Bučar, and L. R. MacGillivray. J. Am. Chem. Soc. 2008, 130, 14366-14367.  https://pubs.acs.org/doi/10.1021/ja804863u
4. ”Coding a coordination-driven self-assembly via a hydrogen-bond-directed solid- state synthesis: An unexpected chiral capsule” T. D. Hamilton, D.-K. Bucar, and L. R. MacGillivray. Chem. Commun. 2007, 1603-1604. 10.1039/B700748E
5. “A Polyhedral Host Constructed Using a Linear Template” T. D. Hamilton, G. S. Papaefstathiou and L. R. MacGillivray. J. Am. Chem. Soc. 2002, 124, 11606- 11607. https://pubs.acs.org/doi/10.1021/ja0278281

Orcid ID: https://orcid.org/0000-0001-8936-4342
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• Porphyrins and related compounds
• Sustainable synthetic approaches