José Carlos Menéndez

1. Synthetic methodology: Development of multiple bond-forming reactions, specially multicomponent and domino reactions in the area of heterocyclic chemistry. Application of these reactions to diversity-oriented synthesis in the area of drug discovery.
2. Medicinal chemistry: Application of multitarget strategies in the areas of neurodegenerative diseases and chemotherapy of neglected infectious diseases (tuberculosis, leishmaniasis, Chagas disease).
3. Small-molecule theranostics.

1. M. Leonardi, V. Estévez, M. Villacampa, J. C. Menéndez. Diversity-oriented synthesis of complex pyrrole-based architectures from very simple starting materials. Advanced Synthesis and Catalysis, 2019, 361, 2054-2074. DOI: 10.1002/adsc.201900044.
2. M. Leonardi, M. Villacampa, J. C. Menéndez. Mechanochemical synthesis of biologically relevant heterocycles, in R. Ballini (Ed.) Green synthetic processes and procedures, Chapter 8. Royal Society of Chemistry, 2019, ISBN 978-1-78801-512-7.
3. M. Leonardi, M. Villacampa, J. C. Menéndez. Multicomponent mechanochemical synthesis. Chemical Science, 2018, 9, 2042 – 2064, DOI: 10.1039/C7SC05370C.
4. M. Leonardi, M. Villacampa, J. C. Menéndez. High-speed vibration milling-promoted synthesis of symmetrical frameworks containing two or three pyrrole units. Beilstein Journal of Organic Chemistry, 2017, 13, 1957-1962. (Special issue on Mechanochemistry), DOI:10.3762/bjoc.13.190.
5. M. Leonardi, M. Villacampa, J. C. Menéndez. Mild and general synthesis of pyrrolo[2,1-a]isoquinolines and related frameworks from pyrrole precursors derived from a mechanochemical multicomponent reaction. Journal of Organic Chemistry, 2017, 82, 2570-2578. DOI: 10.1021/acs.joc.6b02995).
6. V. Estévez, V. Sridharan, S. Sabaté, M. Villacampa, J. C. Menéndez. Three-component synthesis of pyrrole-related nitrogen heterocycles by a Hantzsch-type process: Comparison between conventional and high-speed vibration milling conditions. Asian Journal of Organic Chemistry, 2016, 5, 652–662, DOI: 10.1002/ajoc.201600061.
7. V. Estévez, M. Villacampa, J. C. Menéndez. Concise synthesis of atorvastatin lactone under high-speed vibration milling conditions. Organic Chemistry Frontiers, 2014, 1, 458-463. DOI: 10.1039/C4QO00052H.
8. V. Estévez, M. Villacampa, J. C. Menéndez. Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions. A generalization of the Hantzsch pyrrole synthesis. Chemical Communications, 2013, 49, 591-593. DOI: 10.1039/C2CC38099D.

1. B. S. Vachan, M. Karuppasamy, P. Vinoth, S. Vivek Kumar, S. Perumal, V. Sridharan, J. C. Menéndez. Organic transformations in water catalyzed by proline and its derivatives. Advanced Synthesis and Catalysis, 2020, 362, 87-110. DOI: 10.1002/adsc.201900558.
2. I. Muthukrishnan, V. Sridharan, J. C. Menéndez. Progress in the chemistry of tetrahydroquinolines. Chemical Reviews, 2019, 119, 5057−5191. DOI: 10.1021/acs.chemrev.8b00567.
3. M. Staderini, M. Piquero, M. A. Abengózar, M. Nachér-Vázquez G. Romanelli, P. López-Alvarado, L. Rivas, M. L. Bolognesi, J. C. Menéndez. Structure-activity relationships and mechanistic studies of novel 4-(polyamino)styrylquinoline derivatives active against Leishmania strains. European Journal of Medicinal Chemistry, 2019, 171, 38-53.
4. J. F. González, D. Rocchi, T. Tejero, P. Merino, J. C. Menéndez. One-pot synthesis of functionalized carbazoles via a CAN-catalyzed multicomponent process comprising a C-H activation step. Journal of Organic Chemistry, 2017, 82, 7492−7502; DOI: 10.1021/acs.joc.7b01199.
5. I. Gameiro, P. Michalska, G. Tenti, A. Cores, I. Buendía, A. I. Rojo, N. D. Georgakopoulos, J. M. Hernández-Guijo, M. T. Ramos, G. Wells, M. G. López, A. Cuadrado, J. C. Menéndez, R. León. Discovery of the first dual GSK3β inhibitor / Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease. Scientific Reports, 2017, 7, article nr. 45701, pp. 1-15. DOI: 10.1038/srep45701.
6. L. De Petrocellis, F. J. Arroyo, P. Orlando, A. Schiano Moriello, R. M. Vitale, P. Amodeo, A. Sánchez, C. Roncero, G. Bianchini, M. A. Martín, P. López-Alvarado, J. C. Menéndez. Tetrahydroisoquinoline-derived urea and 2,5-diketopiperazine derivatives as selective antagonists of the transient receptor potential melastatin 8 (TRPM8) channel receptor and antiprostate cancer agents. Journal of Medicinal Chemistry, 2016, 59, 5661-5683. DOI: 10.1021/acs.jmedchem.5b01448.
7. G. Bianchini, P. Ribelles, D. Becerra, M. T. Ramos, J. C. Menéndez. Efficient synthesis of 2-acylquinolines based on an aza-vinylogous Povarov reaction. Organic Chemistry Frontiers, 2016, 3, 412–422. DOI: 10.1039/C6QO00037A.
8. M. Staderini, M. L. Bolognesi, J. C. Menéndez. Lewis acid–catalyzed generation of C-C and C-N bonds on π-deficient heterocyclic substrates. Advanced Synthesis and Catalysis, 2015, 357, 185-195. DOI: 10.1002/adsc.201400674.
9. G. Tenti, E. Parada, R. León, J. Egea, S. Martínez-Revelles, A. M. Briones, V. Sridharan, M. G. López, M. T. Ramos, J. C. Menéndez. New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury. Journal of Medicinal Chemistry, 2014, 57, 4313-4323. DOI: 10.1021/jm500263v.
10. P. V. A. Raja, G. Tenti, S. Perumal, J. C. Menéndez. A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction. Chemical Communications, 2014, 50, 12270-12272. DOI: 10.1039/C4CC01791A.

Orcid ID: https://orcid.org/0000-0002-0560-8416
Google Scholar: https://scholar.google.com/citations?user=mROIo74AAAAJ&hl=en&oi=ao
Researchgate: https://www.researchgate.net/profile/J_Carlos_Menendez
Scopus profiles: https://www.scopus.com/authid/detail.uri?origin=resultslist&authorId=6506907063&zone=

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