Martin Beyer

We are interested in the quantitative description of mechanochemical bond activation. To this end, we perform single molecule force spectroscopy of covalently anchored polymers by atomic force microscopy and determine unimolecular reaction rate coefficients for bond rupture events as a function of force and temperature. Quantum chemical methods like COGEF or EFEI are used to describe and simulate experimental data. We have investigated in detail the stability of covalent anchors on silanized glass surfaces, mechanophores like cyclopropane, and the mechanochemistry of the peptide/amide bond. We are also interested in the change of spectroscopic properties of stretched molecules. In this field, quantum chemical description is relatively straightforward, while experiments are extremely difficult.

1. M. F. Pill, A. L. L. East, D. Marx, M. K. Beyer, H. Clausen-Schaumann: Mechanical activation drastically accelerates amide bond hydrolysis, matching enzyme activity. Angew. Chem. Int. Ed. 58, 9787-9790 (2019). DOI: 10.1002/anie.201902752 ; Angew. Chem. 131, 9890-9894 (2019). DOI: 10.1002/ange.201902752
2. M. S. Sammon, M. Ončák, M. K. Beyer: Theoretical simulation of the infrared signature of mechanically stressed polymer solids. Beilstein J. Org. Chem. 13, 1710-1716 (2017). DOI: 10.3762/bjoc.13.165
3. M. F. Pill, K. Holz, N. Preußke, F. Berger, H. Clausen-Schaumann, U. Lüning, M. K. Beyer: Mechanochemical Cycloreversion of Cyclobutane Observed at the Single Molecule Level. Chem. Eur. J. 22, 12034-12039 (2016). DOI: 10.1002/chem.201600866
4. D. Schütze, K. Holz, J. Müller, M.K. Beyer, U. Lüning, B. Hartke: Pinpointing Mechanochemical Bond Rupture by Embedding the Mechanophore into a Macrocycle. Angew. Chem. Int. Ed. 54, 2556-2559 (2015). DOI: 10.1002/anie.201409691 ; Angew. Chem. 127, 2587-2590 (2015). DOI: 10.1002/ange.201409691
5. M. K. Beyer, H. Clausen-Schaumann: Mechanochemistry: The Mechanical Activation of Covalent Bonds. Chem. Rev. 105, 2921-2948 (2005). DOI: 10.1021/cr030697h

1. A. Herburger, E. Barwa, M. Ončák, J. Heller, C. van der Linde, D. M. Neumark, M. K. Beyer: Probing the Structural Evolution of the Hydrated Electron in Water Cluster Anions (H2O)n–, n ≤ 200, by Electronic Absorption Spectroscopy. J. Am. Chem. Soc. 141, 18000-18003 (2019). DOI: 10.1021/jacs.9b10347
2. M. Ončák, T. Taxer, E. Barwa, C. van der Linde, M. K. Beyer: Photochemistry and Spectroscopy of Small Hydrated Magnesium Clusters Mg+(H2O)n, n = 1–5. J. Chem. Phys. 149, 044309 (2018). DOI: 10.1063/1.5037401
3. N. K. Bersenkowitsch, M. Ončák, C. van der Linde, A. Herburger, M. K. Beyer: Photochemistry of glyoxylate embedded in sodium chloride clusters, a laboratory model for tropospheric sea-salt aerosols. Phys. Chem. Chem. Phys. 20, 8143-8151 (2018). DOI: 10.1039/c8cp00399h
4. J. Lengyel, C. van der Linde, M. Fárník, M. K. Beyer: Reaction of CF2Cl2 with Gas-Phase Hydrated Electrons. Phys. Chem. Chem. Phys. 18, 23910-23915 (2016). DOI: 10.1039/C6CP01976E
5. A. Akhgarnusch, R. F. Höckendorf, M. K. Beyer: Thermochemistry of the Reaction of SF6 with Gas Phase Hydrated Electrons: a Benchmark for Nanocalorimetry. J. Phys. Chem. A 119, 9978-9985 (2015). DOI: 10.1021/acs.jpca.5b06975

Orcid ID: https://orcid.org/0000-0001-9373-9266
Google Scholar: https://scholar.google.at/citations?user=d622DbIAAAAJ&hl=en&oi=ao
Researchgate: https://www.researchgate.net/profile/Martin_Beyer3
Scopus profiles: https://publons.com/researcher/1571952/martin-beyer/

• Single molecule force spectroscopy
• Covalent mechanochemistry
• Mechanophore properties
• Quantum chemical description of mechanochemical reactions